p53: The Barrier or Guardian for Cell Dedifferentiation?
نویسندگان
چکیده
منابع مشابه
Neddylating the Guardian Mdm2 Catalyzed Conjugation of Nedd8 to p53
The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptional activity.
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ژورنال
عنوان ژورنال: BioScience
سال: 2014
ISSN: 1525-3244,0006-3568
DOI: 10.1093/biosci/biu133